Rapid viral quasispecies evolution: implications for vaccine and drug strategies
Identifieur interne : 001274 ( Main/Exploration ); précédent : 001273; suivant : 001275Rapid viral quasispecies evolution: implications for vaccine and drug strategies
Auteurs : Isabel S. Novella [États-Unis] ; Esteban Domingo ; John J. Holland [États-Unis]Source :
- Molecular Medicine Today [ 1357-4310 ] ; 1995.
English descriptors
- Teeft :
- Antiviral, Antiviral agents, Antiviral drugs, Complete shift, Diverse quasispecies populations, Encephalitis, Environmental conditions, Epitope, Error threshold, Genome, Hemorrhagic, Human immunodeficiency virus, Human immunodeficiency virus type, Immune, Immune response, Influenza, Limited number, Measles, Mutant, Mutation, Mutation rates, Original variant, Partial shift, Peptide vaccines, Quasispecies, Rapid evolution, Raven press, Replication, Resistant mutants, Subacute sclerosing panencephalitis, Such mutants, Vaccine, Vaccine design, Vaccine development, Viral, Viral proteins, Viral quasispecies, Virus, Virus infections, Virus quasispecies, Virus vaccines.
Abstract
High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising.
Url:
DOI: 10.1016/S1357-4310(95)91551-6
Affiliations:
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Le document en format XML
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